January 25, 2019

Alzheimer’s Can be Reversed!

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by Dr David Perlmutter

I’ve often been quoted as stating that there is no pharmaceutical approach that has meaningful effectiveness on the treatment of Alzheimer’s disease. Unfortunately, I have to continue to make this claim. As was recently reported in the journal Neurology:

Despite great scientific efforts to find treatments for Alzheimer’s disease (AD), only 5 medications are marketed, with limited beneficial effects on symptoms, on a limited proportion of patients, without modification of disease course. The prevalence of AD doubles every 5 years reaching an alarming rate of 50% in those aged 85 years and older. In the context of the demographic trends of modern society, where the elderly are the fastest growing segment of the population, identification of new therapeutic targets that may prevent, delay, or cure AD is critically needed. (italics added).

The authors reemphasize what we know: that there is no silver bullet available now, or in the foreseeable future, that will help with this devastating and fatal condition.

I was discussing this challenge with my close friend and colleague, Dr. Dale Bredesen, last year. He agreed that there was no single approach that was effective in treating this disease, but went further, stating:

Clearly, there is no silver bullet for Alzheimer’s. What we need to do is use silver buckshot.
What Dr. Bredesen meant was that there are multiple issues that are involved in the degeneration of the brain that manifest as Alzheimer’s disease. He posits that an approach that isn’t just focused on finding a single therapy, but rather ameliorates a variety of problematic issues is the key to solving the Alzheimer’s challenge.

He has developed a program that recognizes how multiple problems, including hormone imbalance, low vitamin D levels, toxins, elevated blood glucose, compromised brain glucose metabolism, increased bowel permeability, and many others, conspire to degenerate the brain. He believes that attention to and remediation of these factors may well lead to reversal of Alzheimer’s disease.

We’ve learned that in those with Alzheimer’s disease, many of the brain’s neurons are functional but not functioning. And the cause of this compromise in functionality has been identified and described in scientific journals for years. Basically, a population of brain cells progressively loses the ability to use glucose sugar as a fuel and remain idle. This is the reason that PET scans that measure brain metabolism of glucose are utilized when studying patients with the disease.

New research demonstrates that these idling neurons can be re-powered when ketones, a type of fat made in the body when people are on a ketogenic diet, can allow these brain cells to regain their function. This fact is the reasoning behind Dr. Bredesen’s inclusion of a ketogenic diet as one of the many leverage points in his comprehensive program.

What I’m so excited to report is the fact that Dr. Bredesen’s protocol WORKS. He has now demonstrated that Alzheimer’s disease is indeed reversible!

In his most recent publication, Dr. Bredesen, working with a team of physicians in clinics around the country, demonstrated how a multifaceted approach has proven effective in actually reversing the cognitive decline we see in patients with mild cognitive impairment (MCI), generally considered to be a prelude to Alzheimer’s disease, as well as in patients in whom the diagnosis of Alzheimer’s was already confirmed.

And beyond the improvement in brain function, virtually across the board, the actual case reports reveal how some individuals who were essentially unable to care for themselves were actually able to return to gainful employment.

What’s more, in a previous report Dr. Bredesen describes how some patients show actual, objective improvement in terms of their brain scans that were read by independent radiologists.

As a neurologist, I can tell you that we’ve been trained to believe these improvements in Alzheimer’s patients can’t happen. But it is happening, right now, in clinics around the country.

Developing the solitary, unique and patentable drug, the silver bullet, to treat Alzheimer’s, hasn’t happened, and likely isn’t going to happen. This no doubt explains why Pfizer, the pharmaceutical giant, has now ceased their Alzheimer’s research.

Dr. Bredesen concludes his landmark report stating:

“In summary, a targeted, personalized, precision medicine approach that addresses the multiple potential contributors to cognitive decline for each patient shows promise for the treatment of Alzheimer’s disease and its harbingers, MCI and SCI (subjective cognitive impairment). The improvements documented in the 100 patients reported here provide support for the performance of a prospective, randomized, controlled clinical trial, especially given the current lack of effective treatment for this common and otherwise terminal illness.

“Over the course of my medical career I have been blessed by the opportunity to connect with some incredibly forward-thinking clinicians and researchers around the globe. Nonetheless, this is the first time that I will express that a particular individual, in my opinion, is deserving of the Nobel Prize. Dr. Bredesen has leveraged a paradigm that challenges the standard approach of modern Western medicine. This personalized approach recognizes the fundamental logic in targeting multiple issues to bring about improvement in Alzheimer’s disease. He has shown us that this disease, now affecting some 40 million people around the globe and costing over $1 trillion annually, isn’t a death sentence. Alzheimer’s can be reversed.”

January 23, 2019

9 Foods to Improve Brain Health and Memory

by Dr David Perlmutter As we’ve stated before, one of the most fascinating things about the human brain is that neuroplasticity, the process by which the brain undergoes changes in response to internal and external stimuli, affords us a great deal of control in determining the overall health of our brain. While there are many […]

December 31, 2018

Ketosis and Cognitive Health

by David Perlmutter, M.D., Board-Certified Neurologist There is certainly a lot of discussion these days about the ketogenic diet, especially as it relates to brain function. I thought it would be instructive to review one of the early important research studies in this area as it reveals several very important findings that are worthy of […]

October 24, 2018

Low-Carb Keto Diet: Avoid These Mistakes

By Dr David Perlmutter New to a Low-Carb Keto Diet? Avoid These Common Mistakes The ketogenic diet is one of the most talked about and debated diet trends today. You’ve probably heard celebrities, athletes, and neighbors raving about the benefits of this dietary approach. Interestingly, the science backs up its rapid growth in popularity, as […]

August 15, 2018

BDNF Important Letters to Remember for Brain Health

by Dr David Perlmutter We’ve all come to accept the notion that our brain will continue to shrink as we age. And nowhere is this decline more impactful than in the hippocampus, the brain’s memory center. Researchers measuring the size of the hippocampus using MRI scans demonstrate a clear correlation between shrinkage of the hippocampus […]

August 11, 2018

Wild Blueberries for Brain Health

by Jeffrey Brams for Garden of Life I landed in Quebec City and picked up my rental car. Once I got into the car, my GPS said I’d be driving—due north—for a few hours. Buckled into my rental with my coffee and a great book on Audible, I set out for an adventure. I’d never […]

Opinions expressed on this blog are those of the writer and have not been reviewed by the FDA, CDC or other 'medical authorities'. Therefore, any products discussed are not intended to diagnose, treat, cure, or prevent any disease, but rather are dietary supplements intended solely for nutritional use.

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